International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
Identifieur interne : 002C21 ( Main/Exploration ); précédent : 002C20; suivant : 002C22International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
Auteurs : Hervé Dombret [France] ; John F. Seymour [Australie] ; Aleksandra Butrym [Pologne] ; Agnieszka Wierzbowska [Pologne] ; Dominik Selleslag [Belgique] ; Jun Ho Jang [Corée du Sud] ; Rajat Kumar [Canada] ; James Cavenagh [Royaume-Uni] ; Andre C. Schuh [Canada] ; Anna Candoni [Italie] ; Christian Récher [France] ; Irwindeep Sandhu [Canada] ; Teresa Bernal Del Castillo [Espagne] ; Haifa Kathrin Al-Ali [Allemagne] ; Giovanni Martinelli [Italie] ; Jose Falantes [Espagne] ; Richard Noppeney [Allemagne] ; Richard M. Stone [États-Unis] ; Mark D. Minden [Canada] ; Heidi Mcintyre [États-Unis] ; Steve Songer [États-Unis] ; Lela M. Lucy [États-Unis] ; C. L. Beach [États-Unis] ; Hartmut Döhner [Allemagne]Source :
- Blood [ 0006-4971 ] ; 2015.
Descripteurs français
- KwdFr :
- Agences internationales, Antinéoplasiques antimétabolites (usage thérapeutique), Azacitidine (usage thérapeutique), Crise blastique (anatomopathologie), Crise blastique (traitement médicamenteux), Femelle, Humains, Leucémie aigüe myéloïde (anatomopathologie), Leucémie aigüe myéloïde (mortalité), Leucémie aigüe myéloïde (traitement médicamenteux), Mâle, Pronostic, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Études de suivi, Études prospectives.
- MESH :
- anatomopathologie : Crise blastique, Leucémie aigüe myéloïde.
- mortalité : Leucémie aigüe myéloïde.
- traitement médicamenteux : Crise blastique, Leucémie aigüe myéloïde.
- usage thérapeutique : Antinéoplasiques antimétabolites, Azacitidine, Protocoles de polychimiothérapie antinéoplasique.
- Agences internationales, Femelle, Humains, Mâle, Pronostic, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Études de suivi, Études prospectives.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antimetabolites, Antineoplastic (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Azacitidine (therapeutic use), Blast Crisis (drug therapy), Blast Crisis (pathology), Female, Follow-Up Studies, Humans, International Agencies, Leukemia, Myeloid, Acute (drug therapy), Leukemia, Myeloid, Acute (mortality), Leukemia, Myeloid, Acute (pathology), Male, Neoplasm Staging, Prognosis, Prospective Studies, Survival Rate.
- MESH :
- chemical , therapeutic use : Antimetabolites, Antineoplastic, Azacitidine.
- drug therapy : Blast Crisis, Leukemia, Myeloid, Acute.
- mortality : Leukemia, Myeloid, Acute.
- pathology : Blast Crisis, Leukemia, Myeloid, Acute.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, International Agencies, Male, Neoplasm Staging, Prognosis, Prospective Studies, Survival Rate.
Abstract
Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 vs 6.5 months; Azacitidine safety in patients age ≥65 years with AML (>30% blasts) was consistent with its known safety profile in other trials.
Url:
DOI: 10.1182/blood-2015-01-621664
PubMed: 25987659
PubMed Central: 4504945
Affiliations:
- Allemagne, Australie, Belgique, Canada, Corée du Sud, Espagne, France, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, District de Leipzig, District de Tübingen, Grand Londres, Massachusetts, Midi-Pyrénées, New Jersey, Occitanie (région administrative), Région capitale de Séoul, Saxe (Land), Victoria (État), Île-de-France
- Leipzig, Londres, Melbourne, Paris, Séoul, Toulouse, Ulm
- Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000174
- to stream Pmc, to step Curation: 000174
- to stream Pmc, to step Checkpoint: 000F03
- to stream PubMed, to step Corpus: 002C19
- to stream PubMed, to step Curation: 002B46
- to stream PubMed, to step Checkpoint: 002B46
- to stream Ncbi, to step Merge: 002585
- to stream Ncbi, to step Curation: 002585
- to stream Ncbi, to step Checkpoint: 002585
- to stream Main, to step Merge: 002C21
- to stream Main, to step Curation: 002C21
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts</title>
<author><name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Hôpital Saint Louis, Institut Universitaire d’Hématologie, University Paris Diderot, Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Saint Louis, Institut Universitaire d’Hématologie, University Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Peter MacCallum Cancer Centre, East Melbourne, Australia, and University of Melbourne, Parkville, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Centre, East Melbourne, Australia, and University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Wroclaw Medical University, Wroclaw, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Selleslag, Dominik" sort="Selleslag, Dominik" uniqKey="Selleslag D" first="Dominik" last="Selleslag">Dominik Selleslag</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Algemeen Ziekenhuis Sint-Jan, Brugge, Belgium;</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Algemeen Ziekenhuis Sint-Jan, Brugge</wicri:regionArea>
<wicri:noRegion>Brugge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jang, Jun Ho" sort="Jang, Jun Ho" uniqKey="Jang J" first="Jun Ho" last="Jang">Jun Ho Jang</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Samsung Medical Center, Seoul, Republic of Korea;</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Cancer Care Manitoba, Winnipeg, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Cancer Care Manitoba, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cavenagh, James" sort="Cavenagh, James" uniqKey="Cavenagh J" first="James" last="Cavenagh">James Cavenagh</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Barts Health National Health Service Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuh, Andre C" sort="Schuh, Andre C" uniqKey="Schuh A" first="Andre C." last="Schuh">Andre C. Schuh</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Princess Margaret Cancer Centre, Toronto, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Centre, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Candoni, Anna" sort="Candoni, Anna" uniqKey="Candoni A" first="Anna" last="Candoni">Anna Candoni</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Azienda Ospedaliero Universitaria S. Maria della Misericordia di Udine, Udine, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliero Universitaria S. Maria della Misericordia di Udine, Udine</wicri:regionArea>
<wicri:noRegion>Udine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Recher, Christian" sort="Recher, Christian" uniqKey="Recher C" first="Christian" last="Récher">Christian Récher</name>
<affiliation wicri:level="3"><nlm:aff id="aff11">Centre Hospitalier Universitaire de Toulouse, Toulouse, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sandhu, Irwindeep" sort="Sandhu, Irwindeep" uniqKey="Sandhu I" first="Irwindeep" last="Sandhu">Irwindeep Sandhu</name>
<affiliation wicri:level="1"><nlm:aff id="aff12">University of Alberta Hospital, Edmonton, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernal Del Castillo, Teresa" sort="Bernal Del Castillo, Teresa" uniqKey="Bernal Del Castillo T" first="Teresa" last="Bernal Del Castillo">Teresa Bernal Del Castillo</name>
<affiliation wicri:level="1"><nlm:aff id="aff13">Hospital Central de Asturias, Oviedo, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Central de Asturias, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Ali, Haifa Kathrin" sort="Al Ali, Haifa Kathrin" uniqKey="Al Ali H" first="Haifa Kathrin" last="Al-Ali">Haifa Kathrin Al-Ali</name>
<affiliation wicri:level="3"><nlm:aff id="aff14">Universitätsklinikum Leipzig, Leipzig, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name>
<affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna</wicri:regionArea>
<wicri:noRegion>” Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falantes, Jose" sort="Falantes, Jose" uniqKey="Falantes J" first="Jose" last="Falantes">Jose Falantes</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla</wicri:regionArea>
<wicri:noRegion>Sevilla</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Noppeney, Richard" sort="Noppeney, Richard" uniqKey="Noppeney R" first="Richard" last="Noppeney">Richard Noppeney</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Universitätsklinikum Essen Klinik für Hämatologie, Essen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Essen Klinik für Hämatologie, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Richard M" sort="Stone, Richard M" uniqKey="Stone R" first="Richard M." last="Stone">Richard M. Stone</name>
<affiliation wicri:level="2"><nlm:aff id="aff18">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Minden, Mark D" sort="Minden, Mark D" uniqKey="Minden M" first="Mark D." last="Minden">Mark D. Minden</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Princess Margaret Cancer Centre, Toronto, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Centre, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcintyre, Heidi" sort="Mcintyre, Heidi" uniqKey="Mcintyre H" first="Heidi" last="Mcintyre">Heidi Mcintyre</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lucy, Lela M" sort="Lucy, Lela M" uniqKey="Lucy L" first="Lela M." last="Lucy">Lela M. Lucy</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Beach, C L" sort="Beach, C L" uniqKey="Beach C" first="C. L." last="Beach">C. L. Beach</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<affiliation wicri:level="3"><nlm:aff id="aff20">Universitätsklinikum Ulm, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25987659</idno>
<idno type="pmc">4504945</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504945</idno>
<idno type="RBID">PMC:4504945</idno>
<idno type="doi">10.1182/blood-2015-01-621664</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000174</idno>
<idno type="wicri:Area/Pmc/Curation">000174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000174</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000F03</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F03</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002C19</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C19</idno>
<idno type="wicri:Area/PubMed/Curation">002B46</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B46</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002B46</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B46</idno>
<idno type="wicri:Area/Ncbi/Merge">002585</idno>
<idno type="wicri:Area/Ncbi/Curation">002585</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002585</idno>
<idno type="wicri:doubleKey">0006-4971:2015:Dombret H:international:phase:study</idno>
<idno type="wicri:Area/Main/Merge">002C21</idno>
<idno type="wicri:Area/Main/Curation">002C21</idno>
<idno type="wicri:Area/Main/Exploration">002C21</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts</title>
<author><name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Hôpital Saint Louis, Institut Universitaire d’Hématologie, University Paris Diderot, Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Saint Louis, Institut Universitaire d’Hématologie, University Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Peter MacCallum Cancer Centre, East Melbourne, Australia, and University of Melbourne, Parkville, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Peter MacCallum Cancer Centre, East Melbourne, Australia, and University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Wroclaw Medical University, Wroclaw, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Selleslag, Dominik" sort="Selleslag, Dominik" uniqKey="Selleslag D" first="Dominik" last="Selleslag">Dominik Selleslag</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Algemeen Ziekenhuis Sint-Jan, Brugge, Belgium;</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Algemeen Ziekenhuis Sint-Jan, Brugge</wicri:regionArea>
<wicri:noRegion>Brugge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jang, Jun Ho" sort="Jang, Jun Ho" uniqKey="Jang J" first="Jun Ho" last="Jang">Jun Ho Jang</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Samsung Medical Center, Seoul, Republic of Korea;</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Samsung Medical Center, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Cancer Care Manitoba, Winnipeg, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Cancer Care Manitoba, Winnipeg</wicri:regionArea>
<wicri:noRegion>Winnipeg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cavenagh, James" sort="Cavenagh, James" uniqKey="Cavenagh J" first="James" last="Cavenagh">James Cavenagh</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Barts Health National Health Service Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuh, Andre C" sort="Schuh, Andre C" uniqKey="Schuh A" first="Andre C." last="Schuh">Andre C. Schuh</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Princess Margaret Cancer Centre, Toronto, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Centre, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Candoni, Anna" sort="Candoni, Anna" uniqKey="Candoni A" first="Anna" last="Candoni">Anna Candoni</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Azienda Ospedaliero Universitaria S. Maria della Misericordia di Udine, Udine, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliero Universitaria S. Maria della Misericordia di Udine, Udine</wicri:regionArea>
<wicri:noRegion>Udine</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Recher, Christian" sort="Recher, Christian" uniqKey="Recher C" first="Christian" last="Récher">Christian Récher</name>
<affiliation wicri:level="3"><nlm:aff id="aff11">Centre Hospitalier Universitaire de Toulouse, Toulouse, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sandhu, Irwindeep" sort="Sandhu, Irwindeep" uniqKey="Sandhu I" first="Irwindeep" last="Sandhu">Irwindeep Sandhu</name>
<affiliation wicri:level="1"><nlm:aff id="aff12">University of Alberta Hospital, Edmonton, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernal Del Castillo, Teresa" sort="Bernal Del Castillo, Teresa" uniqKey="Bernal Del Castillo T" first="Teresa" last="Bernal Del Castillo">Teresa Bernal Del Castillo</name>
<affiliation wicri:level="1"><nlm:aff id="aff13">Hospital Central de Asturias, Oviedo, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Central de Asturias, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Ali, Haifa Kathrin" sort="Al Ali, Haifa Kathrin" uniqKey="Al Ali H" first="Haifa Kathrin" last="Al-Ali">Haifa Kathrin Al-Ali</name>
<affiliation wicri:level="3"><nlm:aff id="aff14">Universitätsklinikum Leipzig, Leipzig, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name>
<affiliation wicri:level="1"><nlm:aff id="aff15">Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna</wicri:regionArea>
<wicri:noRegion>” Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falantes, Jose" sort="Falantes, Jose" uniqKey="Falantes J" first="Jose" last="Falantes">Jose Falantes</name>
<affiliation wicri:level="1"><nlm:aff id="aff16">Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla</wicri:regionArea>
<wicri:noRegion>Sevilla</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Noppeney, Richard" sort="Noppeney, Richard" uniqKey="Noppeney R" first="Richard" last="Noppeney">Richard Noppeney</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Universitätsklinikum Essen Klinik für Hämatologie, Essen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Essen Klinik für Hämatologie, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Richard M" sort="Stone, Richard M" uniqKey="Stone R" first="Richard M." last="Stone">Richard M. Stone</name>
<affiliation wicri:level="2"><nlm:aff id="aff18">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Minden, Mark D" sort="Minden, Mark D" uniqKey="Minden M" first="Mark D." last="Minden">Mark D. Minden</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Princess Margaret Cancer Centre, Toronto, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Centre, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcintyre, Heidi" sort="Mcintyre, Heidi" uniqKey="Mcintyre H" first="Heidi" last="Mcintyre">Heidi Mcintyre</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lucy, Lela M" sort="Lucy, Lela M" uniqKey="Lucy L" first="Lela M." last="Lucy">Lela M. Lucy</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Beach, C L" sort="Beach, C L" uniqKey="Beach C" first="C. L." last="Beach">C. L. Beach</name>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<affiliation wicri:level="3"><nlm:aff id="aff20">Universitätsklinikum Ulm, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antimetabolites, Antineoplastic (therapeutic use)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Azacitidine (therapeutic use)</term>
<term>Blast Crisis (drug therapy)</term>
<term>Blast Crisis (pathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>International Agencies</term>
<term>Leukemia, Myeloid, Acute (drug therapy)</term>
<term>Leukemia, Myeloid, Acute (mortality)</term>
<term>Leukemia, Myeloid, Acute (pathology)</term>
<term>Male</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agences internationales</term>
<term>Antinéoplasiques antimétabolites (usage thérapeutique)</term>
<term>Azacitidine (usage thérapeutique)</term>
<term>Crise blastique (anatomopathologie)</term>
<term>Crise blastique (traitement médicamenteux)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Leucémie aigüe myéloïde (anatomopathologie)</term>
<term>Leucémie aigüe myéloïde (mortalité)</term>
<term>Leucémie aigüe myéloïde (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimetabolites, Antineoplastic</term>
<term>Azacitidine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Crise blastique</term>
<term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Blast Crisis</term>
<term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blast Crisis</term>
<term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Crise blastique</term>
<term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques antimétabolites</term>
<term>Azacitidine</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>International Agencies</term>
<term>Male</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Agences internationales</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 vs 6.5 months; <italic>P</italic>
= .1009).</p>
</list-item>
<list-item><p>Azacitidine safety in patients age ≥65 years with AML (>30% blasts) was consistent with its known safety profile in other trials.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Canada</li>
<li>Corée du Sud</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Leipzig</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Massachusetts</li>
<li>Midi-Pyrénées</li>
<li>New Jersey</li>
<li>Occitanie (région administrative)</li>
<li>Région capitale de Séoul</li>
<li>Saxe (Land)</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Leipzig</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Séoul</li>
<li>Toulouse</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name>
</region>
<name sortKey="Recher, Christian" sort="Recher, Christian" uniqKey="Recher C" first="Christian" last="Récher">Christian Récher</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
</region>
</country>
<country name="Pologne"><noRegion><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
</noRegion>
<name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Selleslag, Dominik" sort="Selleslag, Dominik" uniqKey="Selleslag D" first="Dominik" last="Selleslag">Dominik Selleslag</name>
</noRegion>
</country>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Jang, Jun Ho" sort="Jang, Jun Ho" uniqKey="Jang J" first="Jun Ho" last="Jang">Jun Ho Jang</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name>
</noRegion>
<name sortKey="Minden, Mark D" sort="Minden, Mark D" uniqKey="Minden M" first="Mark D." last="Minden">Mark D. Minden</name>
<name sortKey="Sandhu, Irwindeep" sort="Sandhu, Irwindeep" uniqKey="Sandhu I" first="Irwindeep" last="Sandhu">Irwindeep Sandhu</name>
<name sortKey="Schuh, Andre C" sort="Schuh, Andre C" uniqKey="Schuh A" first="Andre C." last="Schuh">Andre C. Schuh</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cavenagh, James" sort="Cavenagh, James" uniqKey="Cavenagh J" first="James" last="Cavenagh">James Cavenagh</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Candoni, Anna" sort="Candoni, Anna" uniqKey="Candoni A" first="Anna" last="Candoni">Anna Candoni</name>
</noRegion>
<name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Bernal Del Castillo, Teresa" sort="Bernal Del Castillo, Teresa" uniqKey="Bernal Del Castillo T" first="Teresa" last="Bernal Del Castillo">Teresa Bernal Del Castillo</name>
</noRegion>
<name sortKey="Falantes, Jose" sort="Falantes, Jose" uniqKey="Falantes J" first="Jose" last="Falantes">Jose Falantes</name>
</country>
<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Al Ali, Haifa Kathrin" sort="Al Ali, Haifa Kathrin" uniqKey="Al Ali H" first="Haifa Kathrin" last="Al-Ali">Haifa Kathrin Al-Ali</name>
</region>
<name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<name sortKey="Noppeney, Richard" sort="Noppeney, Richard" uniqKey="Noppeney R" first="Richard" last="Noppeney">Richard Noppeney</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Stone, Richard M" sort="Stone, Richard M" uniqKey="Stone R" first="Richard M." last="Stone">Richard M. Stone</name>
</region>
<name sortKey="Beach, C L" sort="Beach, C L" uniqKey="Beach C" first="C. L." last="Beach">C. L. Beach</name>
<name sortKey="Lucy, Lela M" sort="Lucy, Lela M" uniqKey="Lucy L" first="Lela M." last="Lucy">Lela M. Lucy</name>
<name sortKey="Mcintyre, Heidi" sort="Mcintyre, Heidi" uniqKey="Mcintyre H" first="Heidi" last="Mcintyre">Heidi Mcintyre</name>
<name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4504945 |texte= International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25987659" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |