Serveur d'exploration sur les relations entre la France et l'Australie

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International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

Identifieur interne : 002C21 ( Main/Exploration ); précédent : 002C20; suivant : 002C22

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

Auteurs : Hervé Dombret [France] ; John F. Seymour [Australie] ; Aleksandra Butrym [Pologne] ; Agnieszka Wierzbowska [Pologne] ; Dominik Selleslag [Belgique] ; Jun Ho Jang [Corée du Sud] ; Rajat Kumar [Canada] ; James Cavenagh [Royaume-Uni] ; Andre C. Schuh [Canada] ; Anna Candoni [Italie] ; Christian Récher [France] ; Irwindeep Sandhu [Canada] ; Teresa Bernal Del Castillo [Espagne] ; Haifa Kathrin Al-Ali [Allemagne] ; Giovanni Martinelli [Italie] ; Jose Falantes [Espagne] ; Richard Noppeney [Allemagne] ; Richard M. Stone [États-Unis] ; Mark D. Minden [Canada] ; Heidi Mcintyre [États-Unis] ; Steve Songer [États-Unis] ; Lela M. Lucy [États-Unis] ; C. L. Beach [États-Unis] ; Hartmut Döhner [Allemagne]

Source :

RBID : PMC:4504945

Descripteurs français

English descriptors

Abstract

Key Points

Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 vs 6.5 months; P = .1009).

Azacitidine safety in patients age ≥65 years with AML (>30% blasts) was consistent with its known safety profile in other trials.


Url:
DOI: 10.1182/blood-2015-01-621664
PubMed: 25987659
PubMed Central: 4504945


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
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<name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
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<name sortKey="Sandhu, Irwindeep" sort="Sandhu, Irwindeep" uniqKey="Sandhu I" first="Irwindeep" last="Sandhu">Irwindeep Sandhu</name>
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<nlm:aff id="aff12">University of Alberta Hospital, Edmonton, Canada;</nlm:aff>
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<wicri:regionArea>University of Alberta Hospital, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
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</author>
<author>
<name sortKey="Bernal Del Castillo, Teresa" sort="Bernal Del Castillo, Teresa" uniqKey="Bernal Del Castillo T" first="Teresa" last="Bernal Del Castillo">Teresa Bernal Del Castillo</name>
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<nlm:aff id="aff13">Hospital Central de Asturias, Oviedo, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Central de Asturias, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Al Ali, Haifa Kathrin" sort="Al Ali, Haifa Kathrin" uniqKey="Al Ali H" first="Haifa Kathrin" last="Al-Ali">Haifa Kathrin Al-Ali</name>
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<nlm:aff id="aff14">Universitätsklinikum Leipzig, Leipzig, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Leipzig, Leipzig</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
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</affiliation>
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<author>
<name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology and Medical Oncology “L. e A. Seràgnoli,” Bologna</wicri:regionArea>
<wicri:noRegion>” Bologna</wicri:noRegion>
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</author>
<author>
<name sortKey="Falantes, Jose" sort="Falantes, Jose" uniqKey="Falantes J" first="Jose" last="Falantes">Jose Falantes</name>
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<nlm:aff id="aff16">Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Virgen del Rocio/Instituto de BioMedicinia de Sevilla, Sevilla</wicri:regionArea>
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</author>
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<name sortKey="Noppeney, Richard" sort="Noppeney, Richard" uniqKey="Noppeney R" first="Richard" last="Noppeney">Richard Noppeney</name>
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<nlm:aff id="aff17">Universitätsklinikum Essen Klinik für Hämatologie, Essen, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Essen Klinik für Hämatologie, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stone, Richard M" sort="Stone, Richard M" uniqKey="Stone R" first="Richard M." last="Stone">Richard M. Stone</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Minden, Mark D" sort="Minden, Mark D" uniqKey="Minden M" first="Mark D." last="Minden">Mark D. Minden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff9">Princess Margaret Cancer Centre, Toronto, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Centre, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mcintyre, Heidi" sort="Mcintyre, Heidi" uniqKey="Mcintyre H" first="Heidi" last="Mcintyre">Heidi Mcintyre</name>
<affiliation wicri:level="2">
<nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
<affiliation wicri:level="2">
<nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Lucy, Lela M" sort="Lucy, Lela M" uniqKey="Lucy L" first="Lela M." last="Lucy">Lela M. Lucy</name>
<affiliation wicri:level="2">
<nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
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</author>
<author>
<name sortKey="Beach, C L" sort="Beach, C L" uniqKey="Beach C" first="C. L." last="Beach">C. L. Beach</name>
<affiliation wicri:level="2">
<nlm:aff wicri:cut="; and" id="aff19">Celgene Corporation, Summit, NJ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Celgene Corporation, Summit</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">Universitätsklinikum Ulm, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Ulm, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antimetabolites, Antineoplastic (therapeutic use)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Azacitidine (therapeutic use)</term>
<term>Blast Crisis (drug therapy)</term>
<term>Blast Crisis (pathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>International Agencies</term>
<term>Leukemia, Myeloid, Acute (drug therapy)</term>
<term>Leukemia, Myeloid, Acute (mortality)</term>
<term>Leukemia, Myeloid, Acute (pathology)</term>
<term>Male</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Agences internationales</term>
<term>Antinéoplasiques antimétabolites (usage thérapeutique)</term>
<term>Azacitidine (usage thérapeutique)</term>
<term>Crise blastique (anatomopathologie)</term>
<term>Crise blastique (traitement médicamenteux)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Leucémie aigüe myéloïde (anatomopathologie)</term>
<term>Leucémie aigüe myéloïde (mortalité)</term>
<term>Leucémie aigüe myéloïde (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Antimetabolites, Antineoplastic</term>
<term>Azacitidine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Crise blastique</term>
<term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Blast Crisis</term>
<term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Blast Crisis</term>
<term>Leukemia, Myeloid, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en">
<term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Crise blastique</term>
<term>Leucémie aigüe myéloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Antinéoplasiques antimétabolites</term>
<term>Azacitidine</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>International Agencies</term>
<term>Male</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Agences internationales</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Key Points</title>
<p>
<list list-type="bullet">
<list-item>
<p>Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 vs 6.5 months;
<italic>P</italic>
= .1009).</p>
</list-item>
<list-item>
<p>Azacitidine safety in patients age ≥65 years with AML (>30% blasts) was consistent with its known safety profile in other trials.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
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<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Canada</li>
<li>Corée du Sud</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
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<li>Bade-Wurtemberg</li>
<li>District de Leipzig</li>
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<li>Massachusetts</li>
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<li>Saxe (Land)</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
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<settlement>
<li>Leipzig</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
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<li>Ulm</li>
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<tree>
<country name="France">
<region name="Île-de-France">
<name sortKey="Dombret, Herve" sort="Dombret, Herve" uniqKey="Dombret H" first="Hervé" last="Dombret">Hervé Dombret</name>
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<name sortKey="Recher, Christian" sort="Recher, Christian" uniqKey="Recher C" first="Christian" last="Récher">Christian Récher</name>
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<country name="Australie">
<region name="Victoria (État)">
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<noRegion>
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<name sortKey="Wierzbowska, Agnieszka" sort="Wierzbowska, Agnieszka" uniqKey="Wierzbowska A" first="Agnieszka" last="Wierzbowska">Agnieszka Wierzbowska</name>
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<country name="Belgique">
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<country name="Corée du Sud">
<region name="Région capitale de Séoul">
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<name sortKey="Schuh, Andre C" sort="Schuh, Andre C" uniqKey="Schuh A" first="Andre C." last="Schuh">Andre C. Schuh</name>
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<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Cavenagh, James" sort="Cavenagh, James" uniqKey="Cavenagh J" first="James" last="Cavenagh">James Cavenagh</name>
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<country name="Espagne">
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<name sortKey="Falantes, Jose" sort="Falantes, Jose" uniqKey="Falantes J" first="Jose" last="Falantes">Jose Falantes</name>
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<name sortKey="Stone, Richard M" sort="Stone, Richard M" uniqKey="Stone R" first="Richard M." last="Stone">Richard M. Stone</name>
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<name sortKey="Songer, Steve" sort="Songer, Steve" uniqKey="Songer S" first="Steve" last="Songer">Steve Songer</name>
</country>
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